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KMID : 0384320060270080645
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Korean Journal of Family Medicine
2006 Volume.27 No. 8 p.645 ~ p.651
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Relationship between Serum γ-glutamyltransferase Level and Serum Ferritin Level in Healthy Adults
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Kim Jung-Ha
Lee Hye-Ree
Han Ah-Reum
Lim Ji-Ae
Lee Duk-Chul
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Abstract
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Background: Serum γ-GT is one of the biliary enzymes with the only enzymatic activity capable of cleaving extracellular glutathione, thus originating precursor amino acids for the intracellular resynthesis of glutathione. Several population-based studies have shown a strong cross-sectional association between serum γ-GT concentration and cardiovascular risk factors. And prospective studies showed that serum γ-GT concentration had a prognostic impact on cardiovascular mortality. But, the mechanism by which γ-GT is associated with cardiovascular disease is not elucidated. We hypothesized that there was an association between serum γ-GT and ferritin, a marker of oxidative stress. In this study, we investigated the relationship between serum γ-GT and serum ferritin.
Methods: By reviewing the medical records of 288 healthy adults, we determined the serum levels of γ-GT and ferritin according to age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL-cholesterol, fasting blood sugar, hs-CRP, serum ferritin, AST, ALT, uric acid and smoking history. We studied the relationship between the variables by Pearson correlation coefficients and multiple stepwise regression analysis. Mean values of serum γ-GT according to the smoking history were compared using t-test.
Results: Serum γ-GT correlated positively with serum ferritin (r=0.42; P＜0.001). BMI, triglycerides, total cholesterol, fasting blood sugar, AST and ALT also showed statistically significant correlation. Smokers showed significantly higher serum γ-GT. Serum γ-GT correlated with serum ferritin, ALT, current smoking and triglycerides by multiple stepwise regression analysis.
Conclusion: Serum γ-GT correlated positively with serum ferritin.(J Korean Acad Fam Med 2006;27:645-651)
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KEYWORD
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γ-GT, ferritin, oxidative stress
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